Lyon's two main city centre railway stations (Lyon Part-Dieu and Lyon-Perrache) have connections to all the major European cities.
Book your high-speed (TGV) or regional (TER) train ticket:
SNCF website
Trenitalia France also serves the Lyon Perrache, Lyon Part-Dieu, and Lyon Saint-Éxupéry TGV stations:
Trenitalia website